HEL308 Protein (AA 1-1069) (His tag)
This Recombinant HEL308 protein is expressed in HEK-293 Cells.
产品编号 ABIN7563655
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for HEL308 Protein (AA 1-1069) (His tag) (ABIN7563655)
抗原
See all HEL308 蛋白
HEL308
(DNA Helicase HEL308 (HEL308))
蛋白类型
Recombinant
宿主
小鼠
资源
HEK-293 Cells
纯度
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
质量等级
custom-made
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产品特性
- AA 1-1069
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标记
- This HEL308 protein is labelled with His tag.
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原理
- Predefined custom protein recombinant Helq Protein expressed in mammalian cells.
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序列
- MEDGCPRIRR RVSVRKRNRG NLENLRASPT PAELQPAEDT EDEAAAGSRR RKTGSPEHAQ ENDSEEDMFG DYDSFTESSF LAHVDDLEQR YMQLPECGDR DADSGTKDLC SAGLKNNLRV TTVINLTDPE TSEHGQKQSH LDVPAEPEPG SDLSFDVPSS QILYFENPQN SPEALGDPCT KKTNGDPQKS SHEELVSSHT EQPEPNNDFS NVRAASESSR RKSLKDHLKS TMAGNARAQT PAFPRSKHLR EALLSEEISV AKKAIESPSD DLGPFYSLPS KVRDLYVQLK GIKKLYDWQH TCLTLRSVQE RKNLIYSLPT SGGKTLVAEI LMLQELLCRQ KDVLMILPYV AIVQEKISSL SSFGIELGFF VEEYAGSKGR FPPIKRREKK SLYIATIEKA HSLVNALIET SRLSTLGLVV VDELHMIGEG SRGAILEMTL AKVLYTSKTT QIIGMSATLN NVEDLQAFLK AEYYTSQFRP VELKEFLKVN DTIYEVDSQA ADGMTFSRLL SYKYSEALKK MDPDRLVALV TEVIPNYSCL VFCPSKKNCE NVAEMLCKFL SKDYLNHREK EKCEVIKSLR NIGNGKVCPV LKRTVPFGIA YHHSGLTSEE RKLLEEAYST GVLCLLTCTS TLAAGVNLPA RRVILRAPYV ANTFLKRNQY KQMVGRAGRA GIDTAGESIL LLQEKDKQQV LELISGPLET CCSHLVEEFT KGIQALFLSL IGLKIAASLG DIYQFMSGTF FGVQQKILLK EKSLWEITVD ALEHLTEKGL LQKDSCGDNE GLECHFRITK LGQASFKGAI DLAYCDTLYR DLKKGLEGLV LESLLHLIYL TTPYDLAAQS EPDWMVYFKQ FGQLSPTEQN VAALLGVSES FIGKKAAGQA VRKKVDKNVV NRLYLSFVLY SLLKETNVWS VSEKFNLPRG YIQNLLMGAA SFSSCVLHFC EELEEFWVYK ALLVELTKKL TYCVKAELIP LMEVTGVLEG RAKQLYNAGY RSIMHLANAN PEVLVKTIDH LSRRQARQIV SSAKMLLHEK AEALQGEAEE LLRLPADLPG LGGPSSERAG SHAGDVTLS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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DNA Helicase HEL308 (HEL308) (AA 1-1101) protein (His tag)
custom-made HEL308 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
DNA Helicase HEL308 (HEL308) (AA 275-337) protein (GST tag)HEL308 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- HEL308 (DNA Helicase HEL308 (HEL308))
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别名
- Helq
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背景
- Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase),FUNCTION: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:24005329, PubMed:24005041). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity). Possesses both DNA unwinding and annealing activities (By similarity). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Efficiently unwinds substrates containing 3' overhangs or a D-loop (By similarity). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (By similarity). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (By similarity). {ECO:0000250|UniProtKB:Q8TDG4, ECO:0000269|PubMed:24005041, ECO:0000269|PubMed:24005329}.
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分子量
- 119.1 kDa
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UniProt
- Q2VPA6
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AlphaFold
- Q2VPA6
抗原
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