GPR52 Protein (AA 1-361) (His tag)
This Recombinant GPR52 protein is expressed in HEK-293 Cells.
Quick Overview for GPR52 Protein (AA 1-361) (His tag) (ABIN7562795)
抗原
GPR52
(G Protein-Coupled Receptor 52 (GPR52))
蛋白类型
Recombinant
宿主
小鼠
资源
HEK-293 Cells
纯度
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
质量等级
custom-made
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产品特性
- AA 1-361
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标记
- This GPR52 protein is labelled with His tag.
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原理
- Predefined custom protein recombinant Gpr52 Protein expressed in mammalian cells.
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序列
- MNESRWTEWR ILNMSSSIVN VSEHHSCPLG FGHYSVEDVC IFETVVIVLL TFLIISGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLLV GVTCLVPTLS LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN QLVTPCRLRI CIIMIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS AYFTCFIVCL LYAPAALVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVE ASREAGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCV CAKDQEAQDP KPRRRANSCS I Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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G Protein-Coupled Receptor 52 (GPR52) (AA 1-361) protein (His tag)
custom-made GPR52 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- GPR52 (G Protein-Coupled Receptor 52 (GPR52))
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别名
- Gpr52
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背景
- G-protein coupled receptor 52,FUNCTION: G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000250|UniProtKB:Q9Y2T5, ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228, ECO:0000269|PubMed:28583861}.
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分子量
- 41.3 kDa
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UniProt
- P0C5J4
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AlphaFold
- P0C5J4
抗原
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