TRIM6 Protein (AA 1-488) (His tag)
custom-made
TRIM6
宿主: 小鼠
宿主: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- 抗原 See all TRIM6 蛋白
- TRIM6 (Tripartite Motif Containing 6 (TRIM6))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-488
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This TRIM6 protein is labelled with His tag.
- 原理
- Custom-made recombinant Trim6 Protein expressed in mammalian cells.
- 序列
- MTSTVLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQVCII GNSNNSVFGQ GGRSSCPVCR TSYQPGNLRP NRHLAAIVKR LREVALCPGK QLEVIFCALH GEKLQLFCKE DGKLICWLCE RSQEHRGHHT FLMEEVAQEY QDMFQESLKK LRREQQEAEK LKALIQEKRE SWKSQVEPEK RRIQTEFKQL RSILDREEQR ELKKLEVEER KGLSIIEKAE GDLIHQSQSL KDLISDLEHR CQGSTVELLQ DVGDVTKRSE FWTLRKPQAL PTKLKSLFRA PDLRKMLKVF RELTDVQSYW VDVTLNPQTA NLNLVLSKNR RQVRFVGAQL SEPSSLEEHY DCSVLGSQHF SSGKYYWEVD VSKKTAWILG VCSTPVDPMF SFSQYSSKQG AYSRYQPQCG YWVIGLQCKH EYRAYEDSSP SLLLSMTVPP RRIGIFLDCE AGTVSFYNVT NHGLPIYTFS KYYFPSALCP YFNPCSCIVP MTLRRPTS Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- 特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- 产品特性
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - 纯度
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- 质量等级
- custom-made
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Tripartite Motif Containing 6 (TRIM6) (AA 1-488) protein (His tag)
custom-made TRIM6 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tripartite Motif Containing 6 (TRIM6) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)TRIM6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- The buffer composition is at the discretion of the manufacturer.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C.
- 有效期
- 12 months
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- 抗原
- TRIM6 (Tripartite Motif Containing 6 (TRIM6))
- 别名
- Trim6 (TRIM6 产品)
- 背景
- Tripartite motif-containing protein 6 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM6),FUNCTION: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhancement of RIGI-mediated innate antiviral immune response (By similarity). {ECO:0000250|UniProtKB:Q9C030, ECO:0000269|PubMed:22328504, ECO:0000269|PubMed:24882218}.
- 分子量
- 56.2 kDa
- UniProt
- Q8BGE7
- AlphaFold
- Q8BGE7
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