SH2D1B Protein (AA 1-132) (His tag)
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北京 101111
Quick Overview for SH2D1B Protein (AA 1-132) (His tag) (ABIN7555535)
抗原
See all SH2D1B 蛋白蛋白类型
宿主
资源
纯度
质量等级
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产品特性
- AA 1-132
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标记
- This SH2D1B protein is labelled with His tag.
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原理
- Predefined custom protein recombinant SH2D1B Protein expressed in mammalian cells.
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序列
- MDLPYYHGRL TKQDCETLLL KEGVDGNFLL RDSESIPGVL CLCVSFKNIV YTYRIFREKH GYYRIQTAEG SPKQVFPSLK ELISKFEKPN QGMVVHLLKP IKRTSPSLRW RGLKLELETF VNSNSDYVDV LP Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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!探索我们的目录蛋白和定制蛋白服务选项！Product表达系统ConjugateOriginPrice表达系统 Wheat germConjugate GST tagOrigin HumanPrice 5,782.24 ¥表达系统 Baculovirus infected Insect CellsConjugate His tagOrigin HumanPrice 7,555.65 ¥表达系统 Escherichia coli (E. coli)Conjugate His-IF2DI TagOrigin HumanPrice 4,668.87 ¥表达系统 Escherichia coli (E. coli)Conjugate His-SUMO TagOrigin HumanPrice 5,126.92 ¥表达系统 HEK-293 CellsConjugate Myc-DYKDDDDK TagOrigin HumanPrice 10,600.77 ¥表达系统 BacteriaConjugate His-SUMO TagOrigin HumanPrice 3,968.25 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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SH2 Domain Containing 1B (SH2D1B) (AA 1-132) protein (His tag)
custom-made SH2D1B 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
SH2 Domain Containing 1B (SH2D1B) (AA 1-132) protein (GST tag)SH2D1B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
SH2 Domain Containing 1B (SH2D1B) (AA 1-132) protein (His tag)SH2D1B 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
SH2 Domain Containing 1B (SH2D1B) protein (Myc-DYKDDDDK Tag)SH2D1B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- SH2D1B (SH2 Domain Containing 1B (SH2D1B))
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别名
- SH2D1B
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背景
- SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2),FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity). {ECO:0000250|UniProtKB:O35324, ECO:0000269|PubMed:11689425, ECO:0000269|PubMed:24687958, ECO:0000305|PubMed:21219180}.
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分子量
- 15.3 kDa
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UniProt
- O14796
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AlphaFold
- O14796
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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