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VEGF 165 protein (Biotin)

This anti- antibody (ABIN7539353) is a Escherichia coli (E. coli) antibody detecting in . Suitable for Human.
产品编号 ABIN7539353
发货至: 中国

Quick Overview for VEGF 165 protein (Biotin) (ABIN7539353)

抗原

VEGF 165

蛋白类型

Recombinant

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大肠杆菌(E. Coli)

纯度

> 95 % by SDS-PAGE and Coomassie stain
  • 标记

    Biotin

    原理

    VEGF165-Biotin

    序列

    APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

    特异性

    Chromosomal location:6p12

    产品特性

    Length (aa):165

    内毒素水平

    < 0.1 ng per μg of human VEGF165
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  • 应用备注

    Tested in a functional ELISA.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    The lyophilized VEGF165-Biotin should be reconstituted in 50 mM acetic acid to a concentration not lower than 50 μg/mL. For long term storage we recommend to add at least 0.1 % human or bovine serum albumin.

    缓冲液

    50 mM acetic acid

    储存条件

    -20 °C,-80 °C

    储存方法

    Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted VEGF165-Biotin should be stored in working aliquots at -20°C.

    有效期

    6 months
  • 抗原

    VEGF 165

    别名

    VEGF165

    背景

    Vascular endothelial growth factor A, VEGFA, VPF, VEGF, MVCD1,Human Vascular Endothelial Growth Factor VEGF165, a 23 kDa protein consisting of 165 amino acid residues, is produced as a homodimer. VEGF is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF165 have been identified, VEGFR-1 (FLT-1), and VEGFR-2 (KDR). Consistent with the endothelial cell-specific action of VEGF165, expression of both receptor genes has been found predominantly but not exclusively on endothelial cells. Expression of VEGFR-1 was also found on human monocytes, neutrophils (PMNs), bovine brain pericytes and villous and extra villous trophoblast. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. VEGF165 is also a chemo attractant molecule for monocytes and endothelial cells. 5 different proteins are generated by differential splicing: VEGF121, VEGF145, VEGF165, VEGF189 and VEGF206. The most abundant form is VEGF165. Whereas VEGF121 and VEGF165 are secreted proteins, VEGF145, VEGF189 and VEGF206 are strongly cell-associated. The isoforms VEGF145, VEGF165 and VEGF189 bind to heparin with high affinity. VEGF165 is apparently a homo-dimer, but preparations of VEGF165 show some heterogeneity on SDS gels, depending on the secretion of different glycosylation patterns. All dimeric forms have similar biological activities but their bioavailability is very different. There is good evidence that different cells and tissues express different VEGF isoforms. The other members of this increasing growth factor family are VEGF-B, -C, -D and -E. Another member is the Placenta growth factor PlGF.

    分子量

    38.2 kDa

    基因ID

    7422

    NCBI登录号

    NM_001025366, NP_001020537

    UniProt

    P15692
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