Endothelin 1 Protein (EDN1) (His tag)
Quick Overview for Endothelin 1 Protein (EDN1) (His tag) (ABIN7539311)
抗原
See all Endothelin 1 (EDN1) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Endothelin 1 protein is labelled with His tag.
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原理
- Endothelin-1/ET-1
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序列
- MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH
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产品特性
- Length (aa):204
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Endothelin 1 (EDN1) (AA 113-212) protein (GST tag)
EDN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelin 1 (EDN1) (AA 54-202) (Active) protein (His tag)EDN1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） > 95 % AcA, CC Active
Endothelin 1 (EDN1) (AA 53-90) protein (His-IF2DI Tag)EDN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Endothelin 1 (EDN1) (AA 1-212) protein (GST tag)EDN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelin 1 (EDN1) (AA 53-73) (Active) protein (GST tag)EDN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- water
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缓冲液
- PBS
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- Endothelin 1 (EDN1)
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别名
- Endothelin-1/ET-1
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背景
- Preproendothelin-1, PPET-1, ET-1, EDN1,Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
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分子量
- 26.0 kDa
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基因ID
- 1906
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NCBI登录号
- NM_01955, NP_001946
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UniProt
- P05305
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途径
- Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size
抗原
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