S1PR1 蛋白
This Synthetic Nanodisc S1PR1 protein is expressed in Mammalian Cells.
Quick Overview for S1PR1 蛋白 (ABIN7538533)
抗原
See all S1PR1 蛋白
S1PR1
(Sphingosine-1-Phosphate Receptor 1 (S1PR1))
蛋白类型
Synthetic Nanodisc
宿主
人
资源
Mammalian Cells
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原理
- Human S1PR1 full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 1-382) protein (GST tag)
S1PR1 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, ELISA, AA
Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 1-47) protein (GST tag)S1PR1 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, ELISA, AA
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
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别名
- S1PR1
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背景
- The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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分子量
- The human full length S1PR1 protein has a MW of 42.8kDa
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UniProt
- P21453
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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