Galanin Receptor 1 Protein (GALR1)
Quick Overview for Galanin Receptor 1 Protein (GALR1) (ABIN7538295)
抗原
蛋白类型
宿主
资源
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原理
 - Human GALR1 full length protein-synthetic nanodisc
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产品特性
 - Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
 
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
 - High solubility in aqueous solutions
 - High stability
 - Proteins are in a native membrane environment and remain biologically active
 - No detergent and can be used for cell-based assays
 - No MSP backbone proteins
 
- Intolerant to acids and high concentrations of divalent metal ions
 
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限制
 - 仅限研究用
 
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状态
 - Lyophilized
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缓冲液
 - Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
 - -20 °C,-80 °C
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储存方法
 - Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
 - 12 months
 
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- Galanin Receptor 1 (GALR1)
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别名
 - GALR1
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背景
 - The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
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分子量
 - The human full length GALR1 protein has a MW of 39kDa
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UniProt
 - P47211
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途径
 - cAMP Metabolic Process
 
抗原
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