CCBP2 蛋白
Quick Overview for CCBP2 蛋白 (ABIN7538192)
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See all CCBP2 蛋白蛋白类型
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资源
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                                            原理
- Human ACKR2 full length protein-synthetic nanodisc
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                                            产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
 
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                                            说明
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                        Advantages of Synthetic Nanodiscs: - Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
 - Intolerant to acids and high concentrations of divalent metal ions
 
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                                            限制
- 仅限研究用
 
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                                            状态
- Lyophilized
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                                            缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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                                            储存条件
- -20 °C,-80 °C
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                                            储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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                                            有效期
- 12 months
 
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    - CCBP2 (Chemokine Binding Protein 2 (CCBP2))
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                                            别名
- ACKR2
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                                            背景
- This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members, however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
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                                            分子量
- The human full length ACKR2 protein has a MW of 43.4kDa
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                                            UniProt
- O00590
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