CASR 蛋白
Quick Overview for CASR 蛋白 (ABIN7538156)
抗原
See all CASR 蛋白蛋白类型
宿主
资源
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原理
- Human CASR full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Calcium-Sensing Receptor (CASR) (AA 21-130) protein (GST tag)
CASR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Calcium-Sensing Receptor (CASR) (AA 20-612), (Extracellular) protein (GST tag)CASR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Calcium-Sensing Receptor (CASR) (AA 20-612) protein (His tag)CASR 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- CASR (Calcium-Sensing Receptor (CASR))
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别名
- CASR
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背景
- The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
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分子量
- The human full length CASR protein has a MW of 120.7kDa
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UniProt
- P41180
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途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
抗原
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