CALCRL 蛋白
Quick Overview for CALCRL 蛋白 (ABIN7538154)
抗原
See all CALCRL 蛋白蛋白类型
宿主
资源
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原理
- Human CGRPR-RAMP1 full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Calcitonin Receptor-Like (CALCRL) (AA 1-461) protein (GST tag)
CALCRL 宿主: 人 宿主: 小麦胚 Recombinant AP, ELISA, WB, AA
Calcitonin Receptor-Like (CALCRL) (AA 23-132) protein (GST tag)CALCRL 宿主: 人 宿主: 小麦胚 Recombinant AP, ELISA, WB, AA
Calcitonin Receptor-Like (CALCRL) (AA 23-140) protein (mFc Tag)CALCRL 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Calcitonin Receptor-Like (CALCRL) (AA 23-140) protein (Fc Tag)CALCRL 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Calcitonin Receptor-Like (CALCRL) proteinCALCRL 宿主: 人 宿主: Mammalian Cells MNP Membrane Nanoparticle
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- CALCRL (Calcitonin Receptor-Like (CALCRL))
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别名
- CGRPR
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背景
- The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity.
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分子量
- The human full length CGRPR protein has a MW of 53.0 kDa
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UniProt
- Q16602
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途径
- cAMP Metabolic Process
抗原
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