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AVPR1B 蛋白

This Synthetic Nanodisc AVPR1B protein is expressed in Mammalian Cells.
产品编号 ABIN7538138
发货至: 中国

Quick Overview for AVPR1B 蛋白 (ABIN7538138)

抗原

See all AVPR1B 蛋白
AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

蛋白类型

Synthetic Nanodisc

宿主

  • 3
  • 2
  • 1

资源

  • 3
  • 2
  • 1
Mammalian Cells
  • 原理

    Human V1BR full length protein-synthetic nanodisc

    产品特性

    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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  • 说明

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    有效期

    12 months
  • 抗原

    AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

    别名

    V1BR

    背景

    The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

    分子量

    The human full length V1BR protein has a MW of 47kDa

    UniProt

    P47901

    途径

    Regulation of Systemic Arterial Blood Pressure by Hormones
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