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LGALS1/Galectin 1 蛋白

This Recombinant LGALS1/Galectin 1 protein is expressed in 大肠杆菌（E. Coli）.

产品编号 ABIN7533712

发货至: 中国

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Quick Overview for LGALS1/Galectin 1 蛋白 (ABIN7533712)

抗原

See all LGALS1/Galectin 1 (LGALS1) 蛋白

LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

大肠杆菌（E. Coli）

纯度

> 95 % by SDS-PAGE.

Discover our top product LGALS1 蛋白

原理

Active Recombinant Human Galectin-1/LGALS1 Protein

序列

ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD

特异性

Ala2-Asp135

过滤

0.22 μm filtered

内毒素水平

< 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment

Measured by its ability to agglutinate mouse red blood cells. The ED₅₀ for this effect is 0.5-3 μg/mL.
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Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)
LGALS1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (His-IF2DI Tag)
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (His-IF2DI Tag)
LGALS1 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (GST tag)
LGALS1 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)
LGALS1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 90 % pure SDS

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) protein
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) protein
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (His tag)
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (His-IF2DI Tag)
LGALS1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

限制

仅限研究用
状态

Lyophilized

溶解方式

Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

缓冲液

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

储存条件

-20 °C,-80 °C

储存方法

Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
抗原

LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

别名

Galectin-1/LGALS1

背景

Description: Galectin-1, also known as LGALS1 (lectin, galactoside-binding, soluble 1), is a 135 amino acid (aa), 14 kDa, pleiotropic, Non-glycosylated, monomeric or homodimeric carbohydrate-binding protein of the prototype galectin family. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments, or secreted by non-classical pathways. Secreted Galectin-1 has immunosuppressive and anti-inflammatory properties and suppresses acute and chronic inflammation and autoimmunity. It contributes to negative selection of developing T cells, immunosuppression by regulatory T cells, resolution of the inflammatory response, and inhibition of immune cell migration, inflammatory cytokine production, and mast cell degranulation. Galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.
Name: GAL1, GBP,LGALS1, GAL1, galectin-1,GBP,Galectin 1/LGALS1

基因ID

3956

UniProt

P09382

途径

Carbohydrate Homeostasis