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Cytokeratin 19 Protein (AA 80-400) (His tag)

This Recombinant Cytokeratin 19 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7505316
发货至: 中国

Quick Overview for Cytokeratin 19 Protein (AA 80-400) (His tag) (ABIN7505316)

抗原

See all Cytokeratin 19 (KRT19) 蛋白
Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

蛋白类型

Recombinant

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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 产品特性

    AA 80-400

    标记

    This Cytokeratin 19 protein is labelled with His tag.

    序列

    Glu 80-Leu 400

    产品特性

    A DNA sequence encoding the Human Cytokein19 protein (P08727) (Glu 80-Leu 400) was expressed with a N-His tag.
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 106,314.67 ¥
    表达系统 Cell-free protein synthesis (CFPS)
    Conjugate Strep Tag
    Origin Human
    价格从 172,528.32 ¥

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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

    有效期

    12 months
  • 抗原

    Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

    背景

    Abbreviation: Cytokein19

    Target Synonym: Keratin,type I cytoskeletal 19,KRT19,Keratin-19 (K19)

    Background: Cytokeratin 19 (Keratin, type I cytoskeletal 19, also KRT-19, CK19 and Keratin-19) is a 40-45 kDa, acidic Class I keratin member of the intermediate filament family of proteins. Individual keratins are always expressed in tandem with a second keratin, and these are found in all epithelial cells. The class I KRT-19 heterodimerizes/polymerizes with 50-52 kDa class II KRT-8 (plus KRT-5 and -7) to form 8-10 nm filaments in epidermal stem cells, secretory gland (sweat, mammary, bile duct) simple epithelium, and neuroendocrine epidermal Merkel cells. It may represent a viable marker for skin stem cells. In skin, Cytokeratin 19 forms filaments in the fetal epithelium, and then progressively decreases with age, being virtually absent by age 17. Human Cytokeratin 19 is 400 amino acids (aa) in length. It contains an N-terminal "head" region (aa 1-79) and a subsequent "rod" region (aa 80-387), but is absent a typical C-terminal tail region. Cytokeratin 19 possesses at least 5 utilized phosphorylation sites plus one acetylated Lys residue. Based on other keratins, and the presence of an Asp at position 238, there may be caspase cleavage-generated isoforms. Full length human Cytokeratin 19 (aa 2-400) shares 82 % aa sequence identity with mouse Cytokeratin 19.

    分子量

    Calculated MW: 35.2 kDa

    Observed MW: 38 kDa

    UniProt

    P08727
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