HDAC1 Protein (AA 9-321) (His tag)
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- 抗原 See all HDAC1 蛋白
- HDAC1 (Histone Deacetylase 1 (HDAC1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 9-321
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This HDAC1 protein is labelled with His tag.
- 序列
- Arg 9-Asp 321
- 产品特性
- A DNA sequence encoding the Human HDAC1 protein (Q13547) (Arg 9-Asp 321) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product HDAC1 蛋白
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Histone Deacetylase 1 (HDAC1) (AA 1-482) protein (His tag)
custom-made HDAC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Histone Deacetylase 1 (HDAC1) (AA 1-482) protein (GST tag)HDAC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Histone Deacetylase 1 (HDAC1) (AA 1-482) protein (His tag)custom-made HDAC1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Histone Deacetylase 1 (HDAC1) (AA 183-482) protein (His-IF2DI Tag)HDAC1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Histone Deacetylase 1 (HDAC1) (AA 183-482) protein (GST tag)HDAC1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Histone Deacetylase 1 (HDAC1) (AA 28-137) protein (GST tag)HDAC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- HDAC1 (Histone Deacetylase 1 (HDAC1))
- 别名
- HDAC1 (HDAC1 产品)
- 背景
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Abbreviation: HDAC1
Target Synonym: GON 10,HD1,HDAC 1,Histone deacetylase 1,RPD3L1
Background: Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.
- 分子量
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Calculated MW: 34.32 kDa
Observed MW: 35 kDa
- UniProt
- Q13547
- 途径
- Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis
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