Claudin 4 Protein-VLP (CLDN4) (AA 1-209)
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北京 101111
Quick Overview for Claudin 4 Protein-VLP (CLDN4) (AA 1-209) (ABIN7504302)
抗原
See all Claudin 4 (CLDN4) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 1-209
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原理
- Human Claudin 4 VLP
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序列
- Met1-Val209
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产品特性
- Recombinant Human Claudin 4 VLP is expressed from HEK293.It contains Met1-Val209 (It may have cross reaction with anti-His antibody).
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human Claudin 4 VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA (QC Test).,The purity of Human Claudin 4 VLP is greater than 95% as determined by SEC-HPLC.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 150,642.20 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Claudin 4 (CLDN4) (AA 1-210) protein (His tag)
custom-made CLDN4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 4 (CLDN4) (AA 1-209) protein (His tag)custom-made CLDN4 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 4 (CLDN4) proteinCLDN4 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
Claudin 4 (CLDN4) (AA 1-209) protein (GST tag)CLDN4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Claudin 4 (CLDN4) (AA 145-157) protein (Fc Tag)CLDN4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Claudin 4 (CLDN4) (AA 145-157) protein (mFc Tag)CLDN4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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说明
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Virus-like particles (VLPs) are formed from the outer capsid protein of a virus and are tiny nanoparticles formed by the automatic assembly of one or more capsid proteins. VLPs do not contain viral infectious genomes, so they are relatively safe during production operations. The SAMS™ protein engineering platform has been used to express a series of biotinylated, non-biotinylated, and fluorescently-labeled VLP-displayed antigens. They are suitable for SPR, ELISA, CAR-T positive rate detection, and other experimental scenarios.
Virus-Like Particles (VLPs) are highly immunogenic, meaning that they can elicit a strong immune response in the host. VLPs are recognized by the immune system and are taken up by antigen-presenting cells (APCs) such as dendritic cells. Once taken up by APCs, VLPs are processed and presented to T cells, which can trigger the activation of B cells to produce antibodies against the displayed antigen. Because VLPs resemble the structure and composition of native viruses, they are highly effective at inducing both humoral and cellular immune responses.
Generally, VLPs range in size from approximately 20 to 200 nanometers (nm). Compared to a cell-based immunization approach, their smaller size can optimize the immune response to target the specific antigen displayed on the surface of the engineered VLPs. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Supplied as 0.22μm filtered solution in PBS, 300 mM L-arginine ( pH 7.4).
Notice: If you need it for immunization, water-soluble adjuvant is recommended. -
储存条件
- -80 °C
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储存方法
- Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- Claudin 4 (CLDN4)
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别名
- Claudin 4
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背景
- Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
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分子量
- 23.31 kDa.
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UniProt
- O14493
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途径
- Hepatitis C
抗原
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