Nipah Virus Post-Fusion Glycoprotein (NIV pF) protein (His tag)
This Recombinant Nipah Virus Post-Fusion Glycoprotein protein is expressed in HEK-293 Cells.
产品编号 ABIN7482590
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Nipah Virus Post-Fusion Glycoprotein (NIV pF) protein (His tag) (ABIN7482590)
抗原
Nipah Virus Post-Fusion Glycoprotein (NIV pF)
蛋白类型
Recombinant
宿主
Nipah Virus (NiV)
资源
HEK-293 Cells
纯度
90 %
质量等级
MALS verified
-
-
标记
- His tag
-
原理
- Nipah virus Post-Fusion glycoprotein, His Tag (MALS verified)
-
产品特性
- Nipah virus Post-Fusion glycoprotein, His Tag is expressed from human 293 cells (HEK293).
-
内毒素水平
- 1.0 EU per μg
-
-
-
说明
-
This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 54.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- PBS
-
储存条件
- -20 °C
-
储存方法
- -20°C
-
-
- Nipah Virus Post-Fusion Glycoprotein (NIV pF)
-
别名
- Nipah Virus Post-Fusion Glycoprotein
-
物质类
- Viral Protein
-
背景
- Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.
-
分子量
- 54.5 kDa
抗原
-
You are here:
