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CMKLR1 蛋白

CMKLR1 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
产品编号 ABIN7491613
发货至: 中国
  • 抗原 See all CMKLR1 蛋白
    CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
    蛋白类型
    Synthetic Nanodisc
    宿主
    • 4
    • 2
    资源
    • 2
    • 2
    • 2
    HEK-293 Cells
    原理
    Human CMKLR1 full length protein-synthetic nanodisc
    产品特性
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CMKLR1 蛋白
  • 说明

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
    别名
    CMKLR1 (CMKLR1 产品)
    背景
    Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
    分子量
    The human full length CMKLR1 protein has a MW of 42.3 kDa
    UniProt
    Q99788
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