Malic Enzyme Complex, Mitochondrial (Mod2) 蛋白
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Quick Overview for Malic Enzyme Complex, Mitochondrial (Mod2) 蛋白 (ABIN7491695)
抗原
See all Malic Enzyme Complex, Mitochondrial (Mod2) 蛋白蛋白类型
宿主
资源
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原理
- Human MDR-1 full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Malic Enzyme Complex, Mitochondrial (Mod2) (AA 72-113) protein (Fc Tag)
Mod2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Malic Enzyme Complex, Mitochondrial (Mod2) (AA 1084-1419) protein (His-SUMO Tag)Mod2 宿主: Plasmodium falciparum 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Malic Enzyme Complex, Mitochondrial (Mod2) (AA 1084-1419) protein (His tag)Mod2 宿主: Plasmodium falciparum 宿主: 酵母菌 Recombinant > 90 % SDS
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- Malic Enzyme Complex, Mitochondrial (Mod2)
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别名
- MDR-1
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背景
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
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分子量
- The human full length MDR-1 protein has a MW of 141.5 kDa
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UniProt
- P08183
抗原
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