Quick Overview for Pro BDNF 蛋白 (ABIN7455668)
抗原
Pro BDNF (proBDNF)
(Pro-Brain-Derived Neurotrophic Factor (proBDNF))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
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原理
- Recombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A, R127A, R128A) is expressed.
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产品特性
- Extracellular Domain Protein
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纯化方法
- Affinity purification
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
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别名
- pro-BDNF
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背景
- The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
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分子量
- 25.6 KDa
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UniProt
- P23560
抗原
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