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Quick Overview for GDF5 蛋白 (ABIN7455649)
抗原
See all GDF5 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Growth/Differentiation Factor 5 is produced by our E.coli expression system and the target gene encoding Ala382-Arg501 is expressed.
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产品特性
- Extracellular Domain Protein
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纯化方法
- Affinity purification
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Growth Differentiation Factor 5 (GDF5) (AA 376-495) protein (His-IF2DI Tag)
GDF5 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 382-501) protein (His-IF2DI Tag)GDF5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 28-127) protein (GST tag)GDF5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Growth Differentiation Factor 5 (GDF5) (AA 376-495) protein (His tag)GDF5 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Growth Differentiation Factor 5 (GDF5) proteinGDF5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
Growth Differentiation Factor 5 (GDF5) proteinGDF5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- GDF5 (Growth Differentiation Factor 5 (GDF5))
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别名
- GDF-5
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背景
- Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99 % aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
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分子量
- 13.7 KDa
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UniProt
- P43026
抗原
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