产品编号 ABIN7455613
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for CCL26 蛋白 (ABIN7455613)
抗原
See all CCL26 蛋白
CCL26
(Chemokine (C-C Motif) Ligand 26 (CCL26))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
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原理
- Recombinant Human C-C Motif Chemokine 26 is produced by our E.coli expression system and the target gene encoding Ser27-Leu94 is expressed.
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产品特性
- Extracellular Domain Protein
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纯化方法
- Affinity purification
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Chemokine (C-C Motif) Ligand 26 (CCL26) (AA 24-94) protein (His-IF2DI Tag)
CCL26 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-C Motif) Ligand 26 (CCL26) (AA 1-94) protein (GST tag)CCL26 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
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储存条件
- 4 °C,-20 °C
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储存方法
- Lyophilized protein should be stored at -20°C or lower, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C or lower for 3 months. The product is shipped at ambient temperature. Upon receipt, store it immediately at the proper temperature.
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有效期
- 12 months
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- CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))
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别名
- CCL26
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背景
- Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
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分子量
- Predicted MW is 8.21 Kda. Protein runs at 13KDa under reducing conditions.
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UniProt
- Q9Y258
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途径
- Regulation of Actin Filament Polymerization
抗原
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