SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 319-541, B.1.1.529 - Omicron, RBD) (Fc Tag)
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Quick Overview for SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 319-541, B.1.1.529 - Omicron, RBD) (Fc Tag) (ABIN7490663)
抗原
See all SARS-CoV-2 Spike (SARS-CoV-2 S) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 319-541, B.1.1.529 - Omicron, RBD
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标记
- This SARS-CoV-2 Spike protein is labelled with Fc Tag.
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原理
- Recombinant SARS-CoV-2 RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) protein with C-terminal human Fc tag
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特异性
- S protein RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H)(Arg319-Phe541) hFc(Glu99-Ala330)
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产品特性
- Extracellular Domain Protein
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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SARS-CoV-2 Spike (SARS-CoV-2 S) (Super Stable Trimer) protein (His tag)
SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 16-1188), (Trimer) (Active) protein (His-Avi Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-532), (RBD) (Active) protein (His-Avi Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.1.529 - Omicron), (RBD) (Active) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (E484K), (K417N), (N501Y), (RBD) (Active) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.1.7 - alpha), (RBD) protein (Fc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.617.2 - delta), (RBD) protein (Fc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (RBD) protein (His tag,mFc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (Super Stable Trimer) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.640.2), (RBD) (Active) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
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应用备注
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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说明
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please see Certificate of Analysis for specific instructions of reconstitution.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- SARS-CoV-2 Spike (SARS-CoV-2 S)
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别名
- SARS-CoV-2 S protein
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物质类
- Viral Protein
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背景
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SARS-CoV-2 B.1.1.529 (Omicron) Spike RBD Protein
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as Covid19 (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. The spike protein is a type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which accounts for recognizing the cell surface receptor, ACE2. S2 contains basic elements needed for the membrane fusion. Recent publications indicate that S1-RBD domain can induce virus neutralizing-antibody and T cell response. -
分子量
- predicted molecular mass of 51.2 kDa after removal of the signal peptide.The apparent molecular mass of RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H)-hFc is 55-70 kDa due to glycosylation.
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UniProt
- P0DTC2
抗原
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