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CCR2 Protein-VLP (AA 1-360) (Biotin)

Name: CCR2 Protein-VLP (AA 1-360) (Biotin)
Brand: antibodies-online
SKU: ABIN7448154
Availability: OutOfStock

This VLP CCR2 protein is expressed in HEK-293 Cells.

SEC-HPLC

Biotinylated Human CCR2b VLP captured on SA Chip can bind Anti-CCR2b Antibody with an affinity constant of 5. (CCR2 Protein-VLP (AA 1-360) (Biotin))

SPR

2 images

产品编号 ABIN7448154

发货至: 中国

Quick Overview for CCR2 Protein-VLP (AA 1-360) (Biotin) (ABIN7448154)

抗原

See all CCR2 蛋白

CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

蛋白类型

VLP

生物活性

Active

宿主

人

资源

HEK-293 Cells

应用范围

ELISA, Immunogen (Imm), Surface Plasmon Resonance (SPR), Functional Studies (Func)

纯度

> 95 % as determined by HPLC

Discover our top product CCR2 蛋白

产品特性

AA 1-360

标记

This CCR2 protein is labelled with Biotin.

原理

Biotinylated Human CCR2b Protein-VLP

序列

Met1-Leu360

产品特性

Recombinant Biotinylated Human CCR2b Protein-VLP is expressed from HEK293.It contains Met1-Leu360.

过滤

0.22 μm filtered

内毒素水平

Less than 1EU per μl by the LAL method.

Biological Activity Comment

The affinity constant of 5.24 nM as determined in SPR assay (Biacore T200).
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Product

表达系统

Conjugate

Origin

价格从

CCR2 Protein (AA 1-374) (His tag)

表达系统 HEK-293 Cells

Conjugate His tag

Origin Human

价格从 136,947.45 ¥

CCR2 Protein (AA 1-374) (Strep Tag)

表达系统 Cell-free protein synthesis (CFPS)

Conjugate Strep Tag

Origin Human

价格从 152,621.24 ¥

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Chemokine (C-C Motif) Receptor 2 (CCR2) protein
CCR2 宿主: 人宿主: HEK-293 Cells Synthetic Nanodisc

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-373) protein (His tag)
custom-made CCR2 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-374) protein (His tag)
custom-made CCR2 宿主: 人宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-360) (Active) protein-VLP
CCR2 宿主: 人宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, SPR, Func Active

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-42) protein (mFc Tag)
CCR2 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-42) protein (GST tag)
CCR2 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-55) protein (Fc Tag)
CCR2 宿主: 小鼠宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-42) protein (Fc Tag)
CCR2 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Chemokine (C-C Motif) Receptor 2 (CCR2) protein
CCR2 宿主: 人宿主: 小麦胚 Recombinant AP

Chemokine (C-C Motif) Receptor 2 (CCR2) protein (His tag)
CCR2 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 97 % WB, SDS, Imm, PC

应用备注
- Antibody Discovery: Immunization, Screening, Functional Characterization
- Affinity determination: ELISA, SPR
- In vivo pharmacokinetic analysis
- CMC method development
- CAR-T Positive Rate Detection
- Blood sample determination: ELISA
说明

Virus-like particles (VLPs) are formed from the outer capsid protein of a virus and are tiny nanoparticles formed by the automatic assembly of one or more capsid proteins. VLPs do not contain viral infectious genomes, so they are relatively safe during production operations. The SAMS™ protein engineering platform has been used to express a series of biotinylated, non-biotinylated, and fluorescently-labeled VLP-displayed antigens. They are suitable for SPR, ELISA, CAR-T positive rate detection, and other experimental scenarios.

Virus-Like Particles (VLPs) are highly immunogenic, meaning that they can elicit a strong immune response in the host. VLPs are recognized by the immune system and are taken up by antigen-presenting cells (APCs) such as dendritic cells. Once taken up by APCs, VLPs are processed and presented to T cells, which can trigger the activation of B cells to produce antibodies against the displayed antigen. Because VLPs resemble the structure and composition of native viruses, they are highly effective at inducing both humoral and cellular immune responses.

Generally, VLPs range in size from approximately 20 to 200 nanometers (nm). Compared to a cell-based immunization approach, their smaller size can optimize the immune response to target the specific antigen displayed on the surface of the engineered VLPs.

限制

仅限研究用
状态

Liquid

缓冲液

Supplied as 0.22μm filtered solution in PBS, 300 mM L-Arginine ( pH 7.4).

储存条件

-80 °C

储存方法

Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

有效期

12 months
抗原

CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

别名

CCR2b

背景

The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.

分子量

42.9kDa.

UniProt

P41597-2

途径

cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process