CD33 Protein (CD33) (His tag)
Quick Overview for CD33 Protein (CD33) (His tag) (ABIN7316797)
抗原
See all CD33 蛋白蛋白类型
宿主
资源
纯度
质量等级
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标记
- This CD33 protein is labelled with His tag.
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原理
- Rat Siglec-3 / CD33 Protein, His Tag (MALS verified)
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序列
- Asp 18 - Gln 240
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产品特性
- Rat Siglec-3, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - Gln 240 (Accession # F1LTZ3-1).
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内毒素水平
- 1.0 EU per μg
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说明
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This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.7 kDa. The protein migrates as 37-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- -20°C
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- CD33
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别名
- Siglec-3
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背景
- Synonyms:CD33,SIGLEC3,gp67,Description:Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
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分子量
- 26.7 kDa
抗原
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