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CD33 Protein (CD33) (His tag)

This Recombinant CD33 protein is expressed in HEK-293 Cells.
产品编号 ABIN7316797
发货至: 中国

Quick Overview for CD33 Protein (CD33) (His tag) (ABIN7316797)

抗原

See all CD33 蛋白
CD33

蛋白类型

Recombinant

宿主

  • 35
  • 4
  • 1
大鼠

资源

  • 28
  • 4
  • 3
  • 2
  • 2
  • 1
HEK-293 Cells

纯度

95,00 %

质量等级

MALS verified
  • 标记

    This CD33 protein is labelled with His tag.

    原理

    Rat Siglec-3 / CD33 Protein, His Tag (MALS verified)

    序列

    Asp 18 - Gln 240

    产品特性

    Rat Siglec-3, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - Gln 240 (Accession # F1LTZ3-1).

    内毒素水平

    1.0 EU per μg
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  • 说明

    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.7 kDa. The protein migrates as 37-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    PBS, pH 7.4

    储存条件

    -20 °C

    储存方法

    -20°C
  • 抗原

    CD33

    别名

    Siglec-3

    背景

    Synonyms:CD33,SIGLEC3,gp67,Description:Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

    分子量

    26.7 kDa
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