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CD33 Protein (CD33) (R119G) (Fc Tag)

This Recombinant CD33 protein is expressed in HEK-293 Cells.
产品编号 ABIN7316796
发货至: 中国
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Quick Overview for CD33 Protein (CD33) (R119G) (Fc Tag) (ABIN7316796)

抗原

See all CD33 蛋白
CD33

蛋白类型

Recombinant

宿主

  • 37
  • 6
  • 1
  • 1

资源

  • 26
  • 5
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HEK-293 Cells

纯度

95,00 %
  • 产品特性

    R119G

    标记

    This CD33 protein is labelled with Fc Tag.

    原理

    Human Siglec-3 / CD33 (R119G) Protein, Fc Tag

    序列

    Asp 18 - His 259

    产品特性

    Human Siglec-3 (R119G), Fc Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1 (R119G).

    内毒素水平

    1.0 EU per μg
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  • 说明

    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 64-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

    储存条件

    -20 °C

    储存方法

    -20°C
  • 抗原

    CD33

    别名

    Siglec-3

    背景

    Synonyms:CD33,SIGLEC3,gp67,Description:Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

    分子量

    53.1 kDa
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