CXCL12 蛋白
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北京 101111
Quick Overview for CXCL12 蛋白 (ABIN7232731)
抗原
See all CXCL12 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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原理
- Recombinant human CXCL12a is produced in E. coli
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序列
- KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQV CIDPKLKWIQ EYLEKALNKM olecular Mass7.98kDa by Mass Spec.Purity>97%ActivityEC 50 = 0.62nM determined by Calcium Flux with human CXCR4 cells.SPA Binding assay of CXCL12/SDF-1a to CXCR7 (IC50=14pM) and CXCR4 (IC50=2nM).Endotoxin Level<0.01 EU per 1ug of protein by LAL method.FormLyophi lized.Carrier ProteinNon e.
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产品特性
- Recombinant human CXCL12a is produced in E. coli
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Biological Activity Comment
- EC50 = 0.62nM determined by Calcium Flux with human CXCR4 cells.
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Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) (Active) protein (His tag,GST tag)
CXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 24-89) (Active) protein (Biotin)CXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 97 % by SDS PAGE FACS, CMA Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 1-89) protein (GST tag)CXCL12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His tag)CXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) proteinCXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His tag)CXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His-IF2DI Tag)CXCL12 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His-IF2DI Tag)CXCL12 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge tube prior to resuspending. Recommended at 100 μg/mL in sterile distilled water.
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储存条件
- 4 °C,-20 °C,-80 °C
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- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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别名
- CXCL12a
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背景
- Stromal cell-derived factor 1,CXCL12a and CXCL12b, also known as Stromal Cell-Derived Factor 1a and 1b (SDF-1a and SDF-1b), are small cytokines that belong to the intercrine family. Both forms of CXCL12 are produced by alternate splicing of the same gene. CXCL12 is strongly chemotactic for T- lymphocytes and monocytes, and it plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism. It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumor progression. CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12. In breast cancer, however, increased expression of CXCL12 is associated with a reduced risk of distant metastasis. By blocking CXCR4, a major coreceptor for HIV-1 entry, CXCL12 acts as an endogenous inhibitor of CXCR4-tropic HIV-1 strains. CXCL12 was shown to be expressed in many tissues in mice including brain, thymus, heart, lung, liver, kidney, spleen and bone marrow.,rHuCXCL12a, SDF-1alpha
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分子量
- 7.98 kDa
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途径
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
抗原
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