MUC16 Protein (Fc-Avi Tag,Biotin)
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Quick Overview for MUC16 Protein (Fc-Avi Tag,Biotin) (ABIN7319819)
抗原
See all MUC16 (CA125) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This MUC16 protein is labelled with Fc-Avi Tag,Biotin.
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原理
- Recombinant Human CA125/MUC16 (C-Fc-Avi) Biotinylated
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序列
- Gly12660-Met12923
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产品特性
- Biotinylated Recombinant Human Mucin-16 is produced by our Mammalian expression system and the target gene encoding Gly12660-Met12923 is expressed with a Fc, Avi tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Mucin 16, Cell Surface Associated (CA125) (AA 12660-12923) (Active) protein (His-Avi Tag)
CA125 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Mucin 16, Cell Surface Associated (CA125) (AA 12660-12923) (Active) protein (Biotin,His-Avi Tag)CA125 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Mucin 16, Cell Surface Associated (CA125) (AA 1321-1415) protein (GST tag)CA125 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mucin 16, Cell Surface Associated (CA125) (AA 13810-14451) protein (His tag)CA125 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Mucin 16, Cell Surface Associated (CA125) protein (His tag)CA125 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Mucin 16, Cell Surface Associated (CA125) (AA 12660-12923) protein (Fc Tag,AVI tag,Biotin)CA125 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
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别名
- CA125
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背景
- CA-125,CA125,CA125 ovarian cancer antigen,CA125MUC-16,FLJ14303,MUC16,cell surface associated,mucin 16,mucin-16,MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.
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分子量
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Calculated MW: 57.3 kDa
Observed MW: 80-120 kDa
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基因ID
- 94025
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UniProt
- Q8WXI7
抗原
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