PEA15 蛋白
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北京 101111
Quick Overview for PEA15 蛋白 (ABIN7318180)
抗原
See all PEA15 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein
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序列
- Met 1-Ala130
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产品特性
- Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)
custom-made PEA15 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)custom-made PEA15 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (GST tag)PEA15 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
phosphoprotein Enriched in Astrocytes 15 (PEA15) protein (Myc-DYKDDDDK Tag)PEA15 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
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别名
- PEA15
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背景
- 15 kDa Phosphoprotein Enriched in Astrocytes,Astrocytic Phosphoprotein PEA-15,PEA15,PED,Phosphoprotein Enriched in Diabetes,Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
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分子量
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Calculated MW: 15.3 kDa
Observed MW: 12-16 kDa
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基因ID
- 8682
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UniProt
- Q15121
抗原
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