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PEA15 蛋白

PEA15 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7318180
发货至: 中国
  • 抗原 See all PEA15 蛋白
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    蛋白类型
    Recombinant
    宿主
    • 5
    • 2
    资源
    • 3
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    原理
    Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein
    序列
    Met 1-Ala130
    产品特性
    Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
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    Discover our top product PEA15 蛋白
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 106,314.67 ¥
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    Conjugate Strep Tag
    Origin Human
    价格从 172,528.32 ¥

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  • 说明

    12-16 kDa

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    别名
    PEA15 (PEA15 产品)
    背景

    Background: Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.

    Synonym: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15

    分子量
    15.3 kDa
    UniProt
    Q15121
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