TNNC1 蛋白
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Quick Overview for TNNC1 蛋白 (ABIN7317698)
抗原
See all TNNC1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Troponin C/TNNC1 Protein
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序列
- Met 1-Glu161
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产品特性
- A DNA sequence encoding the human TNNC1 (NP_003271.1) (Met1-Glu161) was expressed and purified.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 150 mM NaCl, 10 mM Na2HPO4, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- TNNC1 (Cardiac Troponin C (TNNC1))
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别名
- TNNC1
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背景
- CMD1Z,CMH13,TN-C,TNC,TNNC,Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.
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分子量
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Calculated MW: 18.4 kDa
Observed MW: 20 kDa
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基因ID
- 7134
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NCBI登录号
- NP_003271
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UniProt
- P63316
抗原
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