CD28 Protein (CD28) (Biotin)
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- 抗原 See all CD28 蛋白
- CD28
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人, Cynomolgus
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资源
- 人细胞
- 标记
- This CD28 protein is labelled with Biotin.
- 原理
- Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated
- 序列
- Asn19-Pro152
- 产品特性
- Biotinylated Recombinant Human T-cell-specific surface glycoprotein CD28 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro152 is expressed with a Fc, Avi tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Anti-CD28 mAb(Cat#A063) at 2μg/ml (100 μl/well) can bind Human/Cynomolgus CD28-Fc-Avi(Cat#CY34). The ED50 of Human/Cynomolgus CD28-Fc-Avi(Cat#CY34) is 0.84 ng/ml.
- Top Product
- Discover our top product CD28 蛋白
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CD28 (CD28) protein (mFc-His Tag)
CD28 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
CD28 (CD28) (AA 19-152) protein (His-Avi Tag)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD28 (CD28) protein (His-Avi Tag,Biotin)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
CD28 (CD28) (AA 19-152) protein (Fc Tag)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD28 (CD28) (AA 19-152) (Active) protein (Fc Tag)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD28 (CD28) (AA 19-152) (Active) protein (Fc Tag,AVI tag,Biotin)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD28 (CD28) (AA 19-152) protein (mFc Tag)CD28 宿主: 人, Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD28 (CD28) (AA 18-153) protein (mFc Tag)CD28 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD28 (CD28) (AA 18-153) protein (His tag)CD28 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD28 (CD28) (Active) protein (His tag)CD28 宿主: 人, Cynomolgus 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
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- 说明
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60-90 kDa
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20mTris-HCl, 150 mM NaCl, pH 8.0.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD28
- 别名
- CD28 (CD28 产品)
- 别名
- Tp44 Protein, CD28RNA Protein, cd28 Protein, CD28 molecule Protein, CD28 antigen Protein, Cd28 molecule Protein, CD28 molecule L homeolog Protein, CD28 Protein, Cd28 Protein, cd28.L Protein
- 背景
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Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Synonym: CD28, CD28 antigen, CD28 Molecule, T-cell-specific surface glycoprotein CD28, Tp44, TP44
- 分子量
- 44.1 kDa
- UniProt
- P10747
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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