WWP2 Protein (His-GST)
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Quick Overview for WWP2 Protein (His-GST) (ABIN7317302)
抗原
See all WWP2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This WWP2 protein is labelled with His-GST.
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原理
- Recombinant Human WWP2 Protein (His & GST Tag)
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序列
- Met 1-Glu870
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产品特性
- A DNA sequence encoding the human WWP2 (O00308) (Met1-Glu870) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) (AA 1-335) protein (GST tag)
WWP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)WWP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)WWP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)WWP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))
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别名
- WWP2
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背景
- AIP2,WWp2-like,WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. WWP2 ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation-induced cell death. It also ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. WWP2 ubiquitinates RPB1 and promotes it to proteasomal degradation.
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分子量
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Calculated MW: 126.7 kDa
Observed MW: 120 kDa
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基因ID
- 11060
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UniProt
- O00308
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途径
- Negative Regulation of Transporter Activity
抗原
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