TWF1 Protein (His-GST)
This Recombinant TWF1 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7317477
发货至:
中国
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Quick Overview for TWF1 Protein (His-GST) (ABIN7317477)
抗原
See all TWF1 蛋白
TWF1
(Twinfilin, Actin-Binding Protein 1 (TWF1))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 84 % as determined by reducing SDS-PAGE.
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标记
- This TWF1 protein is labelled with His-GST.
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原理
- Recombinant Human TWF1/Twinfilin-1 Protein (His & GST Tag)
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序列
- Met 1-Asp 252
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产品特性
- A DNA sequence encoding the human TWF1 isoform 4 (Q12792-4) (Met 1-Asp 252) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Twinfilin, Actin-Binding Protein 1 (TWF1) (AA 1-384) protein (GST tag)
TWF1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Twinfilin, Actin-Binding Protein 1 (TWF1) (AA 100-350) protein (His-IF2DI Tag)TWF1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, 500 mM NaCl, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))
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别名
- TWF1/Twinfilin-1
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背景
- A6,MGC23788,MGC41876,PTK9,Twinfilin-1, also known as Protein A6, Protein tyrosine kinase 9, TWF1 and PTK9, is a cytoplasm protein which belongs to theactin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highly conserved actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals. In addition to the mammalian twinfilin-1, a second protein with approximately 65 % sequence identity to twinfilin-1 exists in mouse and humans. TWF1 / PTK9 is expressed at high levels in the colon, testis, ovary, prostate and lung. It is expressed at lower levels in the brain, bladder and heart. It is not detected in liver. TWF1 / PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. TWF1 / PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
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分子量
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Calculated MW: 57.0 kDa
Observed MW: 50 kDa
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基因ID
- 5756
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UniProt
- Q12792
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途径
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
抗原
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