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TLK2 蛋白

This Recombinant TLK2 protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7317071
发货至: 中国
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Quick Overview for TLK2 蛋白 (ABIN7317071)

抗原

See all TLK2 蛋白
TLK2 (Tousled-Like Kinase 2 (TLK2))

蛋白类型

Recombinant

宿主

  • 5
  • 2

资源

  • 3
  • 2
  • 1
  • 1
Baculovirus infected Insect Cells

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 原理

    Recombinant Human TLK2/PKU-ALPHA Protein

    序列

    Leu 397-Asn772

    产品特性

    A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.
  • 想要此Protein的其他选项吗?

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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 127,054.94 ¥
    表达系统 Cell-free protein synthesis (CFPS)
    Conjugate Strep Tag
    Origin Human
    价格从 145,985.55 ¥

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  • 限制

    仅限研究用
  • 状态

    Frozen, Liquid

    缓冲液

    Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0

    储存条件

    -20 °C

    储存方法

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原

    TLK2 (Tousled-Like Kinase 2 (TLK2))

    别名

    TLK2/PKU-ALPHA

    背景

    Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

    Synonym: HsHPK;PKU-ALPHA

    分子量

    43.6 kDa
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