Thrombomodulin Protein (THBD) (His tag)
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Quick Overview for Thrombomodulin Protein (THBD) (His tag) (ABIN7320771)
抗原
See all Thrombomodulin (THBD) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Thrombomodulin protein is labelled with His tag.
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原理
- Recombinant Mouse Thrombomodulin/THBD Protein (His Tag)
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序列
- Leu17-Ser517
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产品特性
- Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Thrombomodulin (THBD) protein (His tag)
THBD 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Thrombomodulin (THBD)
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别名
- Thrombomodulin/THBD
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背景
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Background: Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.
Synonym: Thrombomodulin, TM, Fetomodulin, CD141, BDCA-3, Thbd
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分子量
- 54.6 kDa
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UniProt
- P15306
抗原
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