Thrombomodulin Protein (THBD) (His tag)
Quick Overview for Thrombomodulin Protein (THBD) (His tag) (ABIN7319438)
抗原
See all Thrombomodulin (THBD) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Thrombomodulin protein is labelled with His tag.
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原理
- Recombinant Human Thrombomodulin/CD141 Protein (His Tag)
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序列
- Ala19-Ser515
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产品特性
- Recombinant Human Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Ala19-Ser515 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Thrombomodulin (THBD) protein (His tag)
THBD 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Thrombomodulin (THBD) protein (His tag)THBD 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Thrombomodulin (THBD)
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别名
- Thrombomodulin/CD141
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背景
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Background: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.
Synonym: Thrombomodulin, THBD, TM, Fetomodulin, CD141, THRM
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分子量
- 52.9 kDa
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UniProt
- P07204
抗原
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