Thrombomodulin Protein (THBD) (His tag)
Quick Overview for Thrombomodulin Protein (THBD) (His tag) (ABIN7198229)
抗原
See all Thrombomodulin (THBD) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Thrombomodulin protein is labelled with His tag.
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原理
- Recombinant Rat Thrombomodulin Protein (His Tag)
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序列
- Met1-Ser517
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产品特性
- A DNA sequence encoding the rat THBD (O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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Thrombomodulin (THBD) protein (His tag)
THBD 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Thrombomodulin (THBD)
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别名
- Thrombomodulin
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背景
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Background: Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
Synonym: THBD
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分子量
- 55.2 kDa
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UniProt
- O35370
抗原
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