产品编号 ABIN7198219
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for TXN 蛋白 (ABIN7198219)
抗原
See all TXN 蛋白
TXN
(Thioredoxin (TXN))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 97 % as determined by reducing SDS-PAGE.
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原理
- Recombinant Human Thioredoxin/TXN Protein
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序列
- Met 1-Val 105
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产品特性
- A DNA sequence encoding the C-terminal segment of human TXN (P10599) (Met 1-Val 105) was expressed and purified.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Measured by its ability to catalyze the reduction of insulin. The reaction leads toprecipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-10 A650/min/mg.
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Thioredoxin (TXN) (AA 1-105) (Active) protein
TXN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS, EAA Active
Thioredoxin (TXN) (AA 1-105) protein (GST tag)TXN 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- TXN (Thioredoxin (TXN))
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别名
- Thioredoxin/TXN
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背景
- ADF,ATL-Derived Factor,SASP,Surface-Associated Sulphydryl Protein,TRDX,TRX,TRX1,TXN,Thioredoxin,Trx,Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein which belongs to thethioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
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分子量
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Calculated MW: 11.7 kDa
Observed MW: 14 kDa
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基因ID
- 7295
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UniProt
- P10599
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途径
- Carbohydrate Homeostasis, Cell RedoxHomeostasis
抗原
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