SUV420H2/KMT5C Protein (His-GST)
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Quick Overview for SUV420H2/KMT5C Protein (His-GST) (ABIN7317449)
抗原
See all SUV420H2/KMT5C (SUV420H2) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This SUV420H2/KMT5C protein is labelled with His-GST.
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原理
- Recombinant Human SUV420H2 Protein (His & GST Tag)
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序列
- Gly 2-Leu 280
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产品特性
- A DNA sequence encoding the amino acid sequence (Gly 2-Leu 280) of human SUV420H2 (NP_116090.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 1-468) protein (His tag)
custom-made SUV420H2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) proteinSUV420H2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, 0.5M NaCl, 30 % Glycerol, 0.05 % Teween, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))
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别名
- SUV420H2
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背景
- KMT5C,Histone-lysine N-methyltransferase SUV420H2, also known as Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Lysine N-methyltransferase 5C, SUV420H2 and KMT5C, is nucleus protein which belongs to thehistone-lysine methyltransferase family and Suvar4-20 subfamily. SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV420H2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). FRAP experiments reveal that SUV420H2 is strongly associated to pericentric heterochromatin. The fraction of SUV420H2 captured and characterized by TAP/MS is a soluble fraction which may be in a stable association with HP1. SUV420H2 may be recruited to heterochromatin in association with HP1, and stably maintained at its heterochromatin sites in an HP1-independent fashion.
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分子量
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Calculated MW: 60.0 kDa
Observed MW: 60 kDa
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基因ID
- 84787
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NCBI登录号
- NP_116090
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UniProt
- Q86Y97
抗原
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