STUB1 蛋白
Quick Overview for STUB1 蛋白 (ABIN7318418)
抗原
See all STUB1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human STUB1 Protein
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序列
- Met 1-Tyr303
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产品特性
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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想要此Protein的其他选项吗？
!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 115,504.49 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 172,528.32 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-304) protein (His tag)
custom-made STUB1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)custom-made STUB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)STUB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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别名
- STUB1
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背景
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Background: E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
Synonym: E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP
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分子量
- 34.9 kDa
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UniProt
- Q9UNE7
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途径
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
抗原
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