SRPK1 Protein (His-GST)
This Recombinant SRPK1 protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7317393
发货至:
中国
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Contact Info
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Quick Overview for SRPK1 Protein (His-GST) (ABIN7317393)
抗原
See all SRPK1 蛋白
SRPK1
(SRSF Protein Kinase 1 (SRPK1))
蛋白类型
Recombinant
宿主
人
资源
Baculovirus infected Insect Cells
纯度
> 80 % as determined by reducing SDS-PAGE.
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标记
- This SRPK1 protein is labelled with His-GST.
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原理
- Recombinant Human SRPK1 Protein (His & GST Tag)
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序列
- Glu 2-Ser 655
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产品特性
- A DNA sequence encoding the human SRPK1 (AAH38292.1) (Glu 2-Ser 655) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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SRSF Protein Kinase 1 (SRPK1) (AA 1-655) protein (GST tag)
SRPK1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA, KAA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % Glycerol, 0.1 mMEDTA, 0.5 mM PMSF, 1 mM TCEP, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- PMSF
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- SRPK1 (SRSF Protein Kinase 1 (SRPK1))
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别名
- SRPK1
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背景
- RP3-422H11.1,SFRSK1,Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein which belongs to theprotein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in the testis, at lower levels than isoform 2. SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. SRPK1 plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. SRPK1 locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. SRPK1 appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
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分子量
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Calculated MW: 102 kDa
Observed MW: 120 kDa
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基因ID
- 6732
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UniProt
- Q96SB4
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途径
- Toll-Like Receptors Cascades
抗原
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