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s100a4 蛋白

This Recombinant s100a4 protein is expressed in HEK-293 Cells.
产品编号 ABIN7197760
发货至: 中国

Quick Overview for s100a4 蛋白 (ABIN7197760)

抗原

See all s100a4 (S100A4) 蛋白
s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

蛋白类型

Recombinant

宿主

  • 13
  • 4
  • 3
  • 3
  • 1
小鼠

资源

  • 15
  • 4
  • 3
  • 1
HEK-293 Cells

纯度

> 85 % as determined by SDS-PAGE
  • 原理

    Recombinant Mouse S100A4 Protein

    序列

    Ala2-Lys101

    产品特性

    A DNA sequence encoding the mouse S100A4 (P07091)(Ala2-Lys101) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.

    内毒素水平

    < 1.0 EU per μg of the protein as determined by the LAL method.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from sterile PBS, pH 7.4

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

    别名

    S100A4

    背景

    Background: S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

    Synonym: 18A2,42a,Capl,FSp1,metastasin,Mts1,PeL98,pk9a

    分子量

    11.7 kDa

    UniProt

    P07091

    途径

    S100 Proteins
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