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S100A3 Protein (His-MBP)

This Recombinant S100A3 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7317649
发货至: 中国
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Quick Overview for S100A3 Protein (His-MBP) (ABIN7317649)

抗原

See all S100A3 蛋白
S100A3 (S100 Calcium Binding Protein A3 (S100A3))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 标记

    This S100A3 protein is labelled with His-MBP.

    原理

    Recombinant Human S100A3/S100E Protein (His & MBP Tag)

    序列

    Met 1-Gln 101

    产品特性

    A DNA sequence encoding the human S100A3 (P33764) (Met 1-Gln 101) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.

    过滤

    0.2 μm filtered

    Biological Activity Comment

    Not validated for activity
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from sterile PBS, 20 % glycerol, pH 7.4
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

    有效期

    12 months
  • 抗原

    S100A3 (S100 Calcium Binding Protein A3 (S100A3))

    别名

    S100A3/S100E

    背景

    S100E,Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

    分子量

    Calculated MW: 55.3 kDa

    Observed MW: 50 kDa

    基因ID

    6274

    UniProt

    P33764

    途径

    S100 Proteins
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