S100A12 蛋白
Quick Overview for S100A12 蛋白 (ABIN7317645)
抗原
See all S100A12 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human S100A12/CAGC Protein (Active)
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序列
- Met 1-Glu 92
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产品特性
- A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized recombinant human S100A12 at 2 μg/ml (100 μl/well) can bind human AGER with a linear range of 0.032-20 μg/ml.
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S100 Calcium Binding Protein A12 (S100A12) (AA 2-92) protein (His-IF2DI Tag)
S100A12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
S100 Calcium Binding Protein A12 (S100A12) (AA 1-92) protein (GST tag)S100A12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- S100A12 (S100 Calcium Binding Protein A12 (S100A12))
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别名
- S100A12/CAGC
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背景
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Background: S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.
Synonym: Protein S100-A12;Calcium-binding protein in amniotic fluid 1;Calgranulin-C;Extracellular newly identified RAGE-binding protein;Migration inhibitory factor-related protein 6;S100 calcium-binding protein A12;Calcitermin;S100A12;CGRP;MRP-6;EN-RAGE
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分子量
- 10.6 kDa
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NCBI登录号
- NP_005612
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途径
- Toll-Like Receptors Cascades, S100 Proteins
抗原
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