S100A11 Protein (AA 1-105)
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北京 101111
Quick Overview for S100A11 Protein (AA 1-105) (ABIN7319485)
抗原
See all S100A11 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 1-105
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原理
- Recombinant Human S100A11 Protein
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序列
- Met1-Thr105
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产品特性
- Recombinant Human S100A11 is produced by our E.coli expression system and the target gene encoding Met1-Thr105 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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S100 Calcium Binding Protein A11 (S100A11) (AA 1-98) protein (His tag)
custom-made S100A11 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
S100 Calcium Binding Protein A11 (S100A11) (AA 1-105) protein (His tag)custom-made S100A11 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
S100 Calcium Binding Protein A11 (S100A11) (AA 1-105) protein (GST tag)S100A11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S100 Calcium Binding Protein A11 (S100A11) (AA 1-105) protein (His-IF2DI Tag)S100A11 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
S100 Calcium Binding Protein A11 (S100A11) (AA 1-98) protein (His tag)S100A11 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, 1 mM DTT, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- S100A11 (S100 Calcium Binding Protein A11 (S100A11))
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别名
- S100A11
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背景
- Calgizzarin,MLN 70,MLN70,Metastatic lymph node gene 70 protein,Protein S100-A11,Protein S100-C,S100 calcium-binding protein A11,S100A11,S100C,S100A11 is a member of the S100 family of calcium binding proteins. Human S100A11 contains two EF hand motifs and shares 82 % amino acid sequence identity with mouse and rat S100A11. It forms covalent homodimers upon transglutamination and also disulfide-linked tetramers. S100A11 is secreted by keratinocytes and can be crosslinked into the cornified envelope of the skin. Dimerization enhances its ability to signal through RAGE on keratinocytes, induce the production of EGF family proteins, and induce cell proliferation. Dimerization also enables S100A11 to bind RAGE on chondrocytes, leading to chondrocyte hypertrophy and catabolism of the cartilage matrix. S100A11 is additionally found in the cytosol where it becomes phosphorylated and translocates to the nucleus in response to DNA damage, RELM alpha exposure, or elevated extracellular calcium concentrations. Calcium also promotes S100A11 association with S100B as well as Annexins A1, A2, and A6. S100A11-Annexin A2 complexes are recruited to sites of plasma membrane damage where they facilitate membrane repair in migrating cancer cells. S100A11 is upregulated in various cancers and supports tumor cell proliferation, invasion, and migration. In addition, S100A11 is produced in the ovary, and it acts on cumulus cells to inhibit oocyte fertilization.
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分子量
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Calculated MW: 11.7 kDa
Observed MW: 12 kDa
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基因ID
- 6282
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UniProt
- P31949
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途径
- S100 Proteins
抗原
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