Reticulon 4 Protein (RTN4) (GST tag)
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Quick Overview for Reticulon 4 Protein (RTN4) (GST tag) (ABIN7317322)
抗原
See all Reticulon 4 (RTN4) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Reticulon 4 protein is labelled with GST tag.
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原理
- Recombinant Human RTN4/NOGO-A Protein (GST Tag)
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序列
- Met 1-Val 185
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产品特性
- A DNA sequence encoding the human RTN4 (NP_065393.1) N-terminal fragment (Met 1-Val 185) was fused with the GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Reticulon 4 (RTN4) (AA 27-447) (Active) protein (His tag)
RTN4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Reticulon 4 (RTN4) (AA 27-447) (Active) protein (His tag)RTN4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Reticulon 4 (RTN4) (AA 27-447) (Active) protein (His tag)RTN4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Reticulon 4 (RTN4) (AA 1-199) protein (GST tag)RTN4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Reticulon 4 (RTN4) (AA 1-1192) protein (GST tag)RTN4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Reticulon 4 (RTN4) (AA 1-185) protein (His-IF2DI Tag)RTN4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 1 mM DTT, 0.2 mM GSH, pH 7.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Reticulon 4 (RTN4)
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别名
- RTN4/NOGO-A
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背景
- ASY,DGU,DKFZp781L1143,HIGM4,NI220/250,NOGO,NOGO-A,NOGOC,NSP,NSP-CL,Nbla00271,Nbla10545,Nogo-B,Nogo-C,RTN-X,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C,UDG,UNG1,UNG15,UNG2,Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein which contains onereticulon domain. Isoform1of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform2 of RTN4 is widely expressed except for the liver. Isoform3of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform4of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.
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分子量
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Calculated MW: 46.2 kDa
Observed MW: 48 kDa
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基因ID
- 57142
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NCBI登录号
- NP_065393
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UniProt
- Q9NQC3
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途径
- Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome
抗原
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