PTPN12 Protein (AA 1-355) (His-GST)
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Quick Overview for PTPN12 Protein (AA 1-355) (His-GST) (ABIN7317538)
抗原
See all PTPN12 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 1-355
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标记
- This PTPN12 protein is labelled with His-GST.
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原理
- Recombinant Human PTPN12 Protein (aa 1-355, His & GST Tag)
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序列
- Met 1-Gln355
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产品特性
- A DNA sequence encoding the human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006. The specific activity is > 15 μmoles/min/mg.
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Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-780) protein (GST tag)
PTPN12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Tyrosine Phosphatase G1 (PTPN12) (AA 2-300) protein (His-IF2DI Tag)PTPN12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Protein Tyrosine Phosphatase G1 (PTPN12) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PTPN12 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
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别名
- PTPN12
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背景
- PTP-PEST,PTPG1,PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobilit.
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分子量
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Calculated MW: 69.4 kDa
Observed MW: 64 kDa
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基因ID
- 5782
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UniProt
- Q05209
抗原
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