PVRIG Protein (mFc Tag)
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- 抗原 See all PVRIG 蛋白
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 人细胞
- 标记
- This PVRIG protein is labelled with mFc Tag.
- 原理
- Recombinant Human PVRIG (C-mFc)
- 序列
- Thr41-Asp171
- 产品特性
- Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a mFc tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Human Nectin-2-His(Cat#C440).The ED50 of Human Nectin-2-His(Cat#C440) is 3.72 ug/ml. 2.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi(Cat#CY73). The ED50 of Biotinylated Human Nectin-2-His-Avi(Cat#CY73) is 0.42 ug/ml.
- Top Product
- Discover our top product PVRIG 蛋白
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Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) protein (mFc Tag)
PVRIG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 41-171) protein (Fc Tag)PVRIG 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 41-171) protein (His tag)PVRIG 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 41-171) protein (Fc Tag)PVRIG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 35-165) protein (Fc-Avi Tag)PVRIG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 35-165) protein (Fc-Avi Tag,Biotin)PVRIG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 41-171) (Active) protein (His tag)PVRIG 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 41-171) (Active) protein (Fc Tag,AVI tag,Biotin)PVRIG 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG) (AA 38-326) protein (GST tag)PVRIG 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- 别名
- PVRIG (PVRIG 产品)
- 别名
- C7orf15 Protein, PVR related immunoglobulin domain containing Protein, PVRIG Protein
- 背景
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Background: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65 % similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Synonym: C7orf15, CD112R, PVRIG, transmembrane protein PVRIG, C7orf15MGC138295, MGC104322, MGC138297, MGC2463
- 分子量
- 40.1 kDa
- UniProt
- Q6DKI7
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