PVRL2 蛋白
Quick Overview for PVRL2 蛋白 (ABIN7318075)
抗原
See all PVRL2 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human CD112/Nectin-2 Protein (Active)
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序列
- Met 1-Leu 360
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产品特性
- The mature form of recombinant human CD112 (NP_002847.1) extracellular domain (Met 1-Leu 360) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized human CD112 at 10 μg/ml (100 μl/well) can bind human DNAM1-Fch with a linear range of 1.25-10 μg/ml.
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Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (His-Avi Tag)
PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-351) protein (His tag)PVRL2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (Fc Tag)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (His-Avi Tag,Biotin)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (mFc Tag)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (His tag)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (Fc Tag)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (His tag)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (Fc Tag,AVI tag,Biotin)PVRL2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 43-182) protein (His tag)PVRL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
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别名
- CD112/Nectin-2
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背景
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Background: Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
Synonym: Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, HveB, Nectin-2, CD112, PVRL2, HVEB, PRR2
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分子量
- 36.2 kDa
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NCBI登录号
- NP_002847
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
抗原
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